醒脑静注射液对急性缺血性中风患者hs-CRP、IL-6及TC水平的影响

Effects of Xingnaojing Injection on hs-CRP、IL-6 and TC in Patients with Acute Ischemic Stroke

目的：观察醒脑静注射液对急性缺血性中风患者超敏C-反应蛋白（high-sensitivity CRP,hs-CRP）、白细胞介素-6（interleukin-6,IL-6）及总胆固醇（total cholesterd,TC）水平的影响并探讨其可能的机理。方法：选取南阳南石医院神经内科在201 3-12~2015-10期间收治的急性缺血性中风患者100例,随机将其分为对照组和观察组,每组50例,对照组患者行常规的内科治疗,观察组患者在行常规的内科治疗基础上,再加用醒脑静注射液静脉滴注治疗,每天一次,连续2周（一个疗程）,在治疗前以及治疗后的d 1、d 3、d 6、d 10、d 14分别采取所有患者的静脉血,并分别检测其hs-CRP、IL-6及TC的水平。结果：所有患者的hs-CRP、IL-6以及TC水平均呈一个缓慢的下降趋势,观察组患者较对照组患者比较其下降的趋势更为显著,差异具有统计学意义（P〈0.05）;观察组患者神经功能康复情况高于对照组,差异有统计学意义（P〈0.05）。结论：醒脑静注射液可以显著降低急性缺血性患者血清中的hs-CRP、IL-6及TC水平,具有一定的保护神经功能的作用。

Objective：To observe the effects of Xingnaojing injection on acute ischemic stroke patients with high-sensitivity CRP（hs-CRP）,interleukin-6（IL-6） and total cholesterd（TC）level,and to explore its possible mechanism.Methods：100 patients with acute ischemic stroke were treated in department of neurology of hospital of Nanyang Nan Shi from December 2013 to October2015.They were randomly divided into observation group and control group,50 cases in each group.Control group patients were given regular treatment,while the patients in observation group were given Xingnaojing injection based on regular treatment,once a day for 2 weeks（one course）.Venous blood of all patients was drawn to detect the levels of hs-CRP,IL-6 and TC before treatment and after treatment for first,3,6,14,10 days.Results：The levels of hs-CRP,IL-6 and TC in all patients showed a slow downward trend,while compared with the control group,the observation group was decreased more significantly（P0.05）.The neurological rehabilitation of observation group were significantly higher than control group（P0.05）.Conclusion：Xingnaojing injection can significantly decrease the level of hs-CRP,IL-6 and TC in serum of patients with acute ischemis level,which has a neuroprotective function.