摘要
尿素通道蛋白（urea transporter,UT）是一类特异性通透尿素的跨膜蛋白,其包括两个亚家族。UT-A亚家族有6个成员（UT-A1~UT-A6）,主要分布在肾脏。UT-B亚家族只有1个成员UT-B。UT-B分布广泛,在红细胞、肾脏、大脑、膀胱、睾丸、血管内皮等多组织器官表达。尿素通道蛋白在肾脏尿液浓缩过程中发挥重要作用,也参与其所表达组织器官的生理功能。该文主要综述尿素通道蛋白的组织分布及其生理学功能。
Urea transporters（UT） are a class of transmembrane proteins that are selectively permeable to urea.There are two UT subfamilies,six members（UT-A1-A6） in UT-A subfamily that are mainly expressed in kidney.There is only one member（UT-B） in UT-B subfamily that is widely distributed in multiple tissues,including the red blood cell,kidney,brain,bladder,testis,etc.Urea transporters play an important role in the urine concentration mechanism,and are also involved in many other physiological functions.In this review article,we summarize the expression localization and physiological functions of urea transporters.
作者
姜涛
杨宝学
JIANG Tao YANG Bao-xue(Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China)
出处
《神经药理学报》
2015年第5期40-48,共9页
Acta Neuropharmacologica
基金
国家自然科学基金项目(No.30870921
No.81170632
No.81261160507)
科技部国际科技合作与交流专项(No.2012DFA11070)
关键词
尿素
尿素通道蛋白
肾脏
尿浓缩机制
生理学功能
urea
urea transporter
kidney
urine concentration
physiological function
