摘要
电压门控性钠通道(voltage gated sodium channel,Nav)在痛觉的产生和传导中具有重要作用。在痛觉传导通路中,Nav1.7选择性表达于小直径外周感觉神经元和交感神经节神经元,可通过强化阈下刺激并设定Nav1.8和Nav1.9激活开放的阈值,从而影响神经元兴奋性。该综述将重点阐述由Nav1.7通道基因突变所致的神经病理性痛的研究进展。Nav1.7可作为治疗疼痛的有效靶点,高选择性的Nav1.7阻断剂将对治疗疼痛具有重要的临床应用价值。
Voltage gated sodium channels（Nav） play important roles in generation and conduction of pain.In pain conduction pathway,Nav1.7 is selectively expressed in smalldiameter peripheral somatic sensory neurons and sympathetic ganglion neurons.Navl.7modulates neuronal excitability through amplifing subthreshold of depolarizations and setting up the thresholds of Navl.8 and Navl.9.This review will focus on the progress of neuropathic pain caused by mutations in Navl.7.Navl.7 can be used as an effective target for the treatment of pain.Highly selective Navl.7 blockers will be of great clinical value in the treatment of pain.
作者
王川
单彬
王琼
张海林
WANG Chuan SHAN Bin WANG Qiong ZHANG Hai-lin(Department of Pharmacology, Hebei Medical University, Shijiazhuang, 050017, China Department of Pharmacy, the Forth Hospital of Hebei Medical University, Shijiazhuang, 050011, China)
出处
《神经药理学报》
2015年第5期49-56,共8页
Acta Neuropharmacologica
基金
国家自然科学基金资助项目(No.31171097
No.31270882)
国家重点基础研究发展计划(973计划)(No.2013CB531302)
河北省自然科学基金资助项目(No.C2014206419)
教育部留学回国人员科研启动基金项目(No.2013-693)
河北省高等学校科学技术研究项目重点项目(No.ZD2015007)
