NGAL在肝硬化继发急性肾损伤中的临床诊断价值分析

Diagnosis value of NGAL in liver cirrhosis patients with secondary acute kidney injury

目的探讨中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在肝硬化继发急性肾损伤(AKI)中的诊断价值。方法选取120例肝硬化患者作为研究对象,回顾性分析其临床资料,根据是否继发AKI分为肝硬化继发AKI组(n=80)与未继发AKI组(n=40),比较两组患者血清NGAL、尿液NGAL水平。然后将肝硬化继发AKI组患者进行AKI分期,比较不同分期组患者血清NGAL、尿液NGAL水平。结果肝硬化继发AKI患者血清和尿液NGAL水平分别为(624.7±42.6)、(1.98±0.36)g/L,未继发AKI患者血清和尿液NGAL水平分别为(59.3±10.4)、(0.56±0.11)g/L,组间比较显示,肝硬化继发AKI组患者血清和尿液NGAL水平明显高于未继发AKI组患者,差异有统计学意义(P<0.05)。AKI分期后,不同AKI分期组间血清和尿液NGAL水平不同(P<0.05),且随着AKI分期增加,血清和尿液NGAL水平升高,组间比较差异均有统计学意义(P<0.05)。结论肝硬化继发AKI患者血清和尿液NAGL水平明显高于未继发AKI者,且随着AKI分期增加其水平明显升高,可以作为肝硬化继发AKI早期诊断的有效指标。

Objective To investigate the diagnosis value of neutrophil gelatinase-associated lipocalin（NGAL）in liver cirrhosis patients with secondary acute kidney injury（AKI）.Methods Totally 120 patients with liver cirrhosis who received therapy in the hospital from January 2014 to December 2015 were selected as research subjects.Clinic materials were retrospectively analyzed,and those patients were divided into group with secondary AKI（n=80）and group without secondary AKI（n=40）,and serum and urine levels of NGAL in the two groups were compared.Then,patients in the group with secondary AKI were divided into three subgroups according to AKI staging,and levels of serum NGAL in groups of different AKI stages were compared.Results The level of serum and urine NGAL in group with secondary AKI was（624.7±42.6）and（1.98±0.36）g/L,which were significantly higher than that in the group without secondary AKI[（59.3±10.4）and（0.56±0.11）g/L]（P〈0.05）.And different AKI subgroups had different levels of serum and urine NGAL levels,the higher the AKI stage,the higher level of serum and urine NGAL（P〈0.05）.Conclusion Level of serum and urine NGAL in cirrhosis patients with secondary AKI is significantly higher than that of patients without secondary AKI,which increases with high AKI stage.And NGAL can be used as an effective early diagnosis index for liver cirrhosis with secondary AKI.