羟乙基淀粉联合呋塞米治疗小儿肾病综合征合并重度水肿的临床研究

Clinical research of hydroxyethyl starch combined with furosemide in treatment of children with nephrotic syndrome complicated with severe edema

目的探讨使用羟乙基淀粉联合呋塞米治疗小儿肾病综合征的临床效果与护理要点。方法将肾内科2015年3月至2016年3月收治的50例肾病综合征出现重度水肿的患儿,按照治疗先后顺序将其分为试验组(25例)与对照组(25例),试验组使用羟乙基淀粉联合呋塞米治疗,对照组采用右旋糖酐治疗。观察两组临床疗效,并总结护理要点。结果对照组有效率为48.0%,试验组有效率为80.0%,试验组明显高于对照组,差异有统计学意义(P<0.05);对照组在知识宣传、用药、皮肤清洁、饮食指导及并发症预防等方面评分较试验组低,差异有统计学意义(P<0.05)。结论对出现肾病综合征合并严重水肿的患儿,临床用药选择羟乙基淀粉联合使用呋塞米加速排尿,并对患儿进行多方面护理,大部分患儿家属对临床服务感到满意且患儿临床治疗效果较好。

Objective To explore the clinical effect and main points of nursing of hydroxyethyl starch combined with furosemide in treatment of children with nephrotic syndrome complicated with severe edema.Methods A total of 50 children with nephrotic syndrome complicated with severe edema from March 2015 to March 2016 were selected and according to the treatment sequence,they were divided into the experimental group（25cases）and control group（25cases）.The experimental group was treated with hydroxyethyl starch combined with furosemide treatment,and control group was treated with dextran treatment.The clinical curative effect of the two groups was observed and main points of nursing were summarized.Results The effective rates of control group and experimental group were 48.0% and 80.0%,respectively.And the rate of experimental group was significantly higher than that of the control group（P〈0.05）.In the control group,the scores of clinical services satisfaction on the knowledge publicity,reasonable drug use,skin cleaning,diet guidance and prevention of complications were significantly lower than that of the experimental group（P〈0.05）.Conclusion Hydroxyethyl starch combined with furosemide in treatment of children with nephrotic syndrome complicated with severe edema could accelerate urination,and families of children feel more satisfied for the clinical service,which has better efficacy.