血清胆红素水平与冠心病病变程度的相关性研究

The relationship between the serum bilirubin and degree of coronary heart disease

目的了解冠心病患者血清胆红素水平与冠心病及其病变严重程度的相关性。方法根据冠状动脉造影纳入符合要求的冠心病患者,并根据SYNTAX评分分为轻度(56例)、中度(51例)、重度(60例)冠心病3组,选取同期住院的非冠心病患者106例作为对照组。检测所有患者血清胆红素水平,比较血清胆红素水平在各组的表达状况及与冠心病病变程度的相关性。结果冠心病组与对照组各组间血清胆红素水平比较,差异有统计学意义(P<0.05)。血清胆红素水平与SYNTAX评分均呈负相关性(P<0.05)。血清总胆红素值诊断试验ROC曲线分析,血清总胆红素在一定程度上能够对重度冠心病患者作做出预测(P<0.05)。结论冠心病患者血清胆红素水平显著降低,并随着冠心病病变程度加重而降低,当血清总胆红素水平低于9.53μmol/L可对重度冠心病做出诊断,血清胆红素水平在冠心病病变程度的诊断中具有重要意义。

Objective To investigate the relationship between serum bilirubin level and the degree of coronary heart disease. Methods Patients with coronary heart disease were selected according to the coronary angiography, and divided into three groups which the patients with mild, moderate and severe coronary heart disease according to the SYNTAX score. And no - CHD patients were selected as control group at the same period in the hospital. All patients were tested the serum bilirubin level, compared the expression of serum bilirubin in each group and investigated the correlation of the degree and the coronary heart disease. Results Serum bilirubin level were statistically significant between CHD group and control group （P 〈 0.05 ）. Pearson correlation analysis showed that serum bilirubin levels were negatively related with the SYNTAX score （P 〈 0.05）. Severe coronary artery disease could be predicted by total bilirubin value to some extent （P 〈 0.05）. Conclusion Serum bilirubin level is significantly decreased in CHD, and it maybe decreased with the severe degree in CHD patients, serum total bilirubin less than 9.53 μmol/L maybe diagnosed the severe coronary heart disease, serum bilirubin level plays a great role in diagnosis different degree of coronary disease.