SNCA基因多态性与帕金森病认知障碍的相关性分析

Analysis on correlation between SNCA gene polymorphism and cognitive disorders of Parkinson′s disease

目的对帕金森病(PD)患者α-突触核蛋白(SNCA)rs356200和rs356165位点的多态性进行研究,探讨SNCA基因多态性与PD认知障碍的相关性。方法选择2014年6月至2015年12月该院神经内科120例PD患者(PD组)和120例健康者(对照组)作为研究对象,PD患者根据是否有认知功能障碍分为认知障碍组和非认知障碍组。对各组患者rs356200及rs356165等位基因频率和基因型进行研究。结果 PD组和对照组rs356200等位基因频率比较差异有统计学意义(P<0.05),PD组和对照组rs356200G/G、A/A和A/G基因型比较差异有统计学意义(P<0.05)。PD组和对照组rs356165等位基因频率比较差异无统计学意义(P>0.05),PD组和对照组rs356165G/G、A/A和A/G基因型比较差异有统计学意义(P<0.05)。PD认知障碍组和非认知障碍组rs356200及rs356165等位基因频率和基因型比较差异均无统计学意义(P>0.05)。结论 PD的发病和SNCA基因rs356200和rs356165位点的多态性有关,PD患者的认知功能障碍和SNCA基因rs356200和rs356165位点的多态性没有显著相关性。

Objective To studyα-synuclein（SNCA）rs356200and rs356165 loci polymorphism in the patients with Parkinson′s disease（PD）and to investigate the correlation between SNCA gene polymorphism and PD cognitive impairment.MethodsOne hundred and twenty cases of PD in our hospital from June 2014 to December 2015 and 120heaalthy people were selected as the research subjects.The PD cases served as the PD group and 120 healthy subjects as control group.The PD cases were also divided into the cognitive impairment group and non-cognitive impairment group according to the cognitive impairment.The rs356200 and rs356165allele frequencies and genotype in each group were studied.Results The rs356200 allele frequency had statistical difference between the PD group and control group（P〈0.05）,the rs356200G/G,A/A and A/G genotype had statistical difference between the PD group and control group（P〈0.05）.The rs356165 allele frequency had no statistical difference between the PD group and the control group（P〈0.05）,the rs356165G/G,A/A and A/G genotype had statistical difference between the PD group and control group（P〉0.05）.The rs356200 and rs356165allele frequencies and genotype had no statistical difference between the cognitive impairment group and non-cognitive impairment group（P〉0.05）.Conclusion The morbidity of PD is related to SNCA gene rs356200 and rs356165sites polymorphism.PD cognitive dysfunction has no significant correlation with SNCA gene rs356200 and rs356165loci polymorphism.