老年2型糖尿病性骨质疏松症患者胰岛素干预后骨密度变化情况观察

The interventional effect of insulin on bone density in type 2 diabetic olderly patients with osteoporosis

目的观察老年2型糖尿病性骨质疏松症患者胰岛素干预9个月后骨密度的变化情况。方法选择老年2型糖尿病性骨质疏松症患者50例,随机分为对照组和胰岛素组,各25例。两组均给予格列吡嗪片、二甲双胍片、朗迪碳酸钙D3片(Ⅱ)治疗,另胰岛素组加用胰岛素降糖治疗。于服药前后测定两组左股骨颈(Femur Neck)、股骨粗隆、Ward's三角骨密度值并作比较。结果胰岛素组治疗9个月后骨密度较治疗前增加(P<0.05),而对照组治疗前后骨密度无明显变化(P>0.05)。结论胰岛素是治疗老年2型糖尿病性骨质疏松症的首选药物,不良反应少,骨质流失少,骨质含量增加。

Objective To explore the interventional effect of insulin on bone density in the type 2 diabetic elderly patients with osteoporosis nine months after the treatment. Methods Fifty type 2 diabetic elderly patients with osteoporosis were randomly divided into the control group and the insulin treatment group,with 25 cases in each group. Both of the two groups were treated with oral antidiabetic agents and calcium carbonate and vitamin D3 Tablets（ Ⅱ）,and the insulin treatment group received an additional injection of insulin. The bone density of the left femoral neck,femoral frochanter and Ward＇s Triangle were measured and compared between the two groups. Results Compared with those in the control group,the bone density in the insulin treatment group was significantly increased nine months after the treatment. There was no significant change in bone density before and after treatment in the control group（ P〈0. 05）. Conclusion Insulin is the first choice for the treatment of osteoporosis in the elderly patients with type 2 diabetes,with the advantages of increasing bone mass,less side effects and reducing bone loss.