加味芩珠凉血方联合他扎罗汀凝胶治疗血热证寻常型银屑病的疗效观察

Observation on the efficacy of modified Qinzhu Liangxue decoction plus tazarotene gel for the treatment of blood-heat syndrome psoriasis vulgaris

目的·观察加味芩珠凉血方联合他扎罗汀凝胶治疗血热证寻常型银屑病的临床疗效。方法·选取96例血热证寻常型银屑病患者,随机分为对照组(n=47)和治疗组(n=49)。对照组服用加味芩珠凉血方,治疗组在对照组基础上加用他扎罗汀凝胶涂抹皮损处。1个月为一疗程,2组均连续治疗2个疗程。观察2组用药前后银屑病面积和严重程度指数(PASI)、生活质量指数(DLQI)及血清细胞因子的变化。结果·2组经治疗后PASI、DLQI及血清中肿瘤坏死因子α(TNF-α)、白介素8(IL-8)和IL-22含量均明显下降,以治疗组更为显著。治疗组总有效率为81.63%,明显高于对照组(70.21%)。结论·加味芩珠凉血方联合他扎罗汀凝胶治疗血热证寻常型银屑病具有显著疗效,其疗效与TNF-α、IL-8、IL-22负调控相关。

Objective · To observe the clinical efficacy of modified Qinzhu Liangxue decoction plus tazarotene gel for the treatment of blood-heat syndrome psoriasis vulgaris. Methods · Ninety-six patients with blood-heat syndrome psoriasis vulgaris were enrolled and randomly assigned to the control group （n=47） and the treatment group （n=49）. The control group received modified Qinzhu Liangxue decoction and the treatment group received modified Qinzhu Liangxue decoction plus tazarotene gel for skin lesions. Both groups were consecutively treated for two courses （one month per course）. Changes in Psoriasis Area and Severity Index （PASI）, Dermatology Life Quality Index （DLQI）, and serum cytokines in two groups were observed before and after treatment. Results · PASI, DLQI, TNF-α, IL-8, and IL-22 in both groups were significantly reduced after treatment, especially in the treatment group. The total effective rate in the treatment group was 81.63%, which was significantly higher than that in the control group （70.21%）. Conclusion · Modified Qinzhu Liangxue decoction plus tazarotene gel have significant efficacy for the treatment of blood-heat syndrome psoriasis vulgaris. The efficacy is associated with the negative regulation of TNF-α, IL-8 and IL-22.