心血管疾病即时检测技术的研究进展

Advances in monitoring of cardiovascular diseases at the point of care

心血管疾病已经成为危害人类健康的第一大类疾病,其治疗效果很大程度上依赖于早期诊断及早期干预.随着微流控技术和纳米技术的飞速发展,目前市场上已有多种基于此技术的心血管即时诊断检测装置;同时,与手机App的结合不仅可以对该装置的检测结果进行读取,还可以直接对生理指标进行测定.本文介绍了该疾病现有即时检测的现状及未来的发展方向,概述了商业化心血管疾病即时诊断装置以及研发中产品原型,阐述了基于智能手机本身或者结合其他装置进行心血管疾病监测的研究进展.未来,基于智能手机的集血样检测、疾病诊断和成像处理于一体的集成化系统将会成为POC检测的新方向.

Cardiovascular diseases（CVDs） are the leading cause of death globally. Most of them are preventable and treatable, which largely depend on timely and effective diagnosis and interventions. Owing to the rapid growth of nanotechnology and microfluidics, many portable devices are developed for monitoring of CVDs at the point-of-care（POC）. In addition, smartphone, as a popular and versatile handheld tool, has been used not only as a reader for microfluidic assays, but also as an analyzer for physiological indexes. In this review, we provide a comprehensive overview of the current status and potential development of POC diagnostics for CVDs, introduce some commercial POC devices and developed prototypes, and present the advances in the monitoring of CVDs based on the smartphone independently or combined with other devices. We envision that an integrated system based on smartphone that enables blood testing, disease examination, and imaging will be the focus of future POC research.