摘要
A new hydrophilic polyhydric corrole （1） and its Ga（III） complex （1-Ga） were synthesized and characterized. Corroles 1 and 1-Ga bind to calf thymus DNA externally and exhibit remarkable photonuclease-like activity. Singlet oxygen （102） was identified as the reactive oxygen species involved. These corroles also exhibit significant photocytotoxicity against HeLa, A549, BEL-7402 and HepG2 tumor cell lines. They mainly accumulated in the nuclei of tumor cells. ROS-mediated mitochondrial damage and intracellular DNA disintegration contributed to the observed photodynamic activity.
A new hydrophilic polyhydric corrole （1） and its Ga（III） complex （1-Ga） were synthesized and characterized. Corroles 1 and 1-Ga bind to calf thymus DNA externally and exhibit remarkable photonuclease-like activity. Singlet oxygen （102） was identified as the reactive oxygen species involved. These corroles also exhibit significant photocytotoxicity against HeLa, A549, BEL-7402 and HepG2 tumor cell lines. They mainly accumulated in the nuclei of tumor cells. ROS-mediated mitochondrial damage and intracellular DNA disintegration contributed to the observed photodynamic activity.
基金
This work was supported by the following institutions： the National Natural Science Foundation of China （NNSFC, Nos. 21371059, 21376099）, the High-Level Personnel Project of Guangdong Province in 2013, and the Joint Natural Science Fund of the Department of Science and Technology and the First Affiliated Hospital of Guangdong Pharmaceutical University （No. GYFYLH201315）, the National Science Foundation of Guangdong Province （No. 2016A030313728）.
