心房颤动患者高敏C反应蛋白与血栓前状态标志物相关性分析

Correlation Analysis between Plasma High-Sensitivity C-Reactive Levels and Biomarks of Prethrombotic State in Patients with Atrial Fibrillation

目的:观察心房颤动(简称房颤)患者血浆高敏C反应蛋白(hs-CRP)、血管性假血友病因子(v WF)、D-二聚体及纤维蛋白原(Fbg)的变化情况并分析其相关性。方法 :选取房颤组95例患者及窦性心律对照组55例患者,比较两组血浆hs-CRP、v WF、D-二聚体及Fbg水平。结果:房颤组hs-CRP、v WF、D-二聚体均高于对照组(P<0.05);Fbg水平在房颤组与对照组的差异无统计学意义(P>0.05)。在房颤组中,hs-CRP与血栓前状态相关指标v WF、Fbg及D-二聚体存在正相关(P<0.05)。结论:房颤患者存在血栓前状态,与炎症反应相关。

Objective ：To analyze correlation between plasmahigh-sensitivity C-reactive（hs-CRP） levels, von Willebrand Factor（v WF）, D-dimmer and fibrinogen（Fbg） in patients with atrial fibrillation（AF）. Methods ：95 AF patientsand 55 normal sinus rhythm patients were enrolled in this study. The levels of plasma v WF, D-dimmer, Fbg and hs-CRP were compared among the groups, respectively. Results ： Compared to control group, plasma hs-CRP,v WF and D-dimmer were significantly increased in AF patients（P〈0.05）. There was no statistic difference of Fbg between two groups（P〈0.05）. In AF patients, plasma hs-CRP levels were correlated with v WF, D-dimmer and Fbg（P〈0.05）. Conclusions ：Prethrombotic state exists in patients with atrial fibrillation and is associated with inflammation.