磷酸奥司他韦胶囊与其他抗病毒药物治疗上呼吸道病毒感染疗效对比

Comparison of the Effect of Oseltamivir Phosphate Capsules and Other Antiviral Drugs for the Treatment of Upper Respiratory Tract Infection

目的:探讨比较磷酸奥司他韦胶囊与其他抗病毒药物治疗上呼吸道病毒感染的临床疗效。方法:本次入选患者为2014年11月至2016年5月来我院发热门诊就诊的上呼吸道感染患者150例,根据随机数学法进行分组,对照组75例,观察组75例,对照组患者给予利巴韦林注射液注射,同时给予维C银翘片口服;观察组患者给予磷酸奥司他韦胶囊口服。观察并记录两组患者的平均退热时间、症状改善时间、治愈时间,并对治疗效果进行评价。结果:观察组患者的平均退热时间、症状改善时间和治愈时间均显著少于对照组(P<0.05)。两组患者经过治疗后,观察组总有效率显著高于对照组(98.7%vs.82.7%,P<0.05)。结论:对于上呼吸道病毒感染的患者给予磷酸奥司他韦胶囊,可有效缩短患者临床症状改善时间,减轻患者痛苦,提高临床治疗效果,值得在临床推广应用。

Objective ： To investigate the clinical curative effect of oseltamivir phosphate capsules and other antiviral drugs for the treatment of upper respiratory tract infection. Methods ： The 150 patients with upper respiratory tract infection from November 2014 to May 2016 of fever clinic in our hospital, were divided randomly into two groups. 75 cases were in the control group and 75 cases were in the observation group. Patients in the control group were treated with ribavirin injection and vitamin C yinqiao Tablets. Patients in the observation group were treated with oral administration of oseltamivir phosphate capsules. The average time of fever patients, the time of symptoms improvement, healing time and the effect of treatment were compared between two groups. Results ： The average defervescence time, the time of symptoms improvement and cure time were less than those of the control group（P〈0.05）. Two groups of patients after treatment, the observation group of 75 patients, 53 cases were markedly effective,21 cases effective, 1 cases ineffective, the total effective 74 cases, the total efficiency in the observation group was significantly higher than that of the control group（98.7% vs 82.7%, P〈0.05）. Conclusion ： Oseltamivir phosphate capsules for the patients with upper respiratory tract infection can effectively shorten the time of the clinical symptoms improvement, reduce the pain of patients, improve the clinical treatment effect. It is worthy of popularizing in clinic.