益肾活血解毒汤对动脉硬化患者血清SOD、NO、ET的影响

Effect of Yishen Huoxue Jiedu Decoction on Serum SOD, NO and ET in the Arteriosclerotic Patient

目的:观察益肾活血解毒汤对动脉粥样硬化(AS)患者血清超氧化物歧化酶(Superoxide Dismutase SOD)、一氧化氮(Nitric Monoxide NO)、内皮素(endothelin,ET)变化的影响,研究其对动脉粥样硬化(AS)影响的相关机制。方法:将患者随机化分组法区分为2组,对照组30例,西医常规药物治疗,治疗组30例,治疗组在常规治疗的前提下加服益肾活血解毒汤,疗程均为30天。治疗前后分别测定2组SOD、NO、ET水平。结果:治疗组治疗后SOD、NO活性增高,ET活性降低,优于对照组(P<0.05)。结论:益肾活血解毒汤可抑制AS进展,其机制可能为抗氧化,保护内皮。

Objective： To observe the effect of Yishen Huoxue Jiedu decoction on serum SOD, NO and ET in the ar- teriosclerotic patient and its mechanism of Atherosclerosis（As）. Methods： the patients were randomly divided into two groups, 30 cases in the control group, 30 cases in the treatment group were treated with routine western medicine, and the treatment group was treated with the traditional western medicine treatment. The treatment group was treated with the decoction of nourishing kidney and promoting blood circulation. The course of treatment was 30 days.Before and after treatment, the levels of ET, NO and SOD were determined in two groups. Results： The activity of and ET in treat- ment group was higher than that in control group（P〈0.05）, and the activity of NO and SOD was increased after treat- ment.Conclusion： Yishen Huoxue Jiedu decoction can inhibit the development of AS by inhibiting platelet aggregation and protecting endothelium cells.