摘要
甲状腺髓样癌（medullary thyroid carcinoma,MTC）起源于甲状腺滤泡旁C细胞,是甲状腺癌中恶性度较高的一类,预后较差.遗传型MTC根据受累腺体不同分为：多发性内分泌腺瘤1,多发性内分泌腺瘤2A和多发性内分泌腺瘤2B.RET基因突变是MTC的主要分子病因学基础,所有这些突变分散在外显子5、8、10、11、13、14、15、16,突变不同,临床表现及预后各不相同.对MTC分子病因学的深入了解能够为MTC的预防、诊断及治疗提供理论依据.
Medullary thyroid carcinoma （MTC） originats from the parafollicular C cells of the thyroid,which is one of the most aggressive forms of thyroid malignancy with the poor prognosis.Hereditary MTC has multiple endocrine neoplasia types 1,2A and 2B.The mutation of RET proto-oncogene has been identified as the main cause of MTC,and all mutations locate among the exons 5,8,10,11,13,14,15,and 16.Mutation analysis of the RET may provide a theoretical basis for the prevention,diagnosis and treatment of MTC.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2016年第11期873-876,共4页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
关键词
甲状腺肿瘤
癌
髓样
原癌基因
突变
Thyroid neoplasms
Carcinoma,medullary
Proto-oncogene
Mutation
