眼睑刷上皮病变研究进展

The research advancement of lid wiper epitheliopathy

眼睑刷位于睑缘内缘处,与皮肤黏膜交界处及Marx线相邻,且与眼球表面相接触,其主要功能是涂布泪液使之形成泪膜及维护眼表细胞的完整性.眼睑刷上皮层发生的病变被命名为眼睑刷上皮病变（lid wiper epitheliopathy,LWE）,其发生与角膜接触镜的配戴以及干眼有关.发病机制主要是眼睑刷与眼球表面,或角膜接触镜表面之间的摩擦力增加,导致上皮层细胞发生病变.有关该病变的研究仍处于起步阶段,对其病因、发病机制、病理改变、检查和治疗手段,以及与其他疾病之间 的关系均有待进一步研究.

The lid wiper locate in the human inner lid border,and is distinct from the mucocutaneous conjunctiva junction （MCJ）/line of Marx.The main functions of lid wiper,which is in closest apposition with the globe are spread the tear film and maintain the integrity of the ocular surface.The term of lid wiper epitheliopathy （LWE） implies a disorder of the epithelial cells in the lid wiper.According to the reports recently published,incidence of LWE in dry eye patients and contact lens wearers is higher.The primary cause of LWE is thought to be increased friction between the lid wiper and ocular or anterior contact lens surface due to inadequate lubrication.However,clinical and fundamental research into LWE is still in its infancy and in many instances equivocal.The etiology,pathogenesis,pathology,the associations between LWE and other ocular diseases,examination and treatment of LWE needs to be research further.