p57、p53、Ki-67在葡萄胎诊断中的应用价值

Application value of p57,p53 and Ki-67 in diagnosis of hydatidiform mole

目的探讨p57、p53、Ki-67对完全性葡萄胎(CHM)、部分性葡萄胎(PHM)及流产水肿绒毛鉴别诊断的价值。方法采用免疫组织化学链霉素抗生物素蛋白-过氧化物酶法检测该院2011年3月至2016年3月收治的10例CHM患者(CHM组)、16例PHM患者(PHM组)、10例自然流产水肿绒毛患者(流产组)、10例人工流产早孕绒毛患者(对照组)临床标本p57、p53、Ki-67蛋白,比较各组p57、p53蛋白表达及Ki-67增殖指数的差异。结果 CHM组、PHM组患者Ki-67增殖指数、p53蛋白表达均明显高于流产组、对照组,CHM组患者p57蛋白表达明显低于PHM组、流产组、对照组,差异均有统计学意义(P<0.05)。结论检测p57可用于对CHM、PHM的鉴别诊断,检测p53、Ki-67可用于对葡萄胎、流产水肿绒毛的鉴别诊断。

Objective To investigate the values of p57,p53 and Ki-67 in the differential diagnosis of complete hydatid-iform mole（CHM）,partial hydatidiform mole（PHM） and abortion hydropic villi. Methods The Ki-67,p53 and p57 protein were detected by using immunohistochemical SP method in 10 cases of CHM（CHM group）,16 cases of PHM（PHM group） and 10 cas-es of natural abortion hydropic villi. The differences of p57 and p53 protein expression and Ki-67 proliferation index were com-pared among groups. Results The Ki-67 proliferation index and p53 protein expression in the CHM group and PHM group were significantly higher than those in the abortion group and control group ,the p57 protein expression in the CHM group was signifi-cantly lower than that in the PHM group,abortion group and control group with statistical difference（P〈0.05）. Conclusion De-tecting p57 can be used in the differential diagnosis of CHM and PHM and detecting Ki-67 and p53 can be used in the differential diagnosis of hydatidiform mole and abortion hydropic villi.