过氧化物还原酶在MAPK信号通路中的调节作用

Regulation Role of Peroxiredoxins Involved into MAPK Signalling Pathways

过氧化物还原酶(Prx)是高度保守的过氧化物酶。Prx的硫氧还蛋白过氧化物酶的活性对维持低水平内源性过氧化氢具有重要意义,并有促进过氧化氢介导的信号功能。丝裂原活化蛋白激酶(MAPK)信号途径介导细胞对包括活性氧(ROS)在内的多种刺激作出反应。文章在此总结Prx可以在MAPK的激活中同时扮演传感器和障碍的证据,并讨论所涉及的具体机制,特别是其与硫氧还蛋白(Trx)的关系。

Peroxiredoxins are highly conserved peroxidases. Although the thioredoxin peroxidase activity of peroxiredoxin（Prx） is important to maintain low levels of endogenous hydrogen peroxide,Prx has also been shown to promote hydrogen peroxide-mediated signalling. Mitogen activated protein kinase（MAPK） signalling pathways mediate cellular responses to a variety of stimuli,including reactive oxygen species（ROS）. Here we review the evidence that Prx can act as both sensors and barriers to the activation of MAPK and discuss the underlying mechanisms involved,focusing in particular on the relationship with thioredoxin.