脂蛋白磷脂酶A2与急性脑梗死及颈动脉斑块稳定性的关系

Relationship of lipoprotein-associated phospholipase A2 with acute cerebral infraction and stability of carotid artery plaque

目的探讨脂蛋白磷脂酶A2(Lp-PLA2)与急性脑梗死(ACI)及颈动脉斑块稳定性的关系。方法采用化学发光免疫分析技术检测94例ACI患者(ACI组)和49例健康体检者(对照组)的血浆Lp-PLA2水平。并根据颈动脉彩色多普勒超声检查结果,分析ACI组颈动脉斑块与Lp-PLA2水平的关系。结果 ACI组血浆Lp-PLA2水平高于对照组(P<0.01)。ACI组中,颈动脉无斑块组、稳定斑块组和不稳定斑块组的Lp-PLA2水平依次升高(P<0.01),且无斑块组与有斑块组Lp-PLA2水平差异亦有统计学意义(P<0.01)。结论 Lp-PLA2可能是ACI的独立危险因素之一,通过监测Lp-PLA2水平可以间接了解颈动脉斑块的稳定性。

Objective To investigate the relationship of lipoprotein-associated phospholipase A2 （Lp-PLA2） with acute cerebral infraction（ACI） and stability of carotid artery plaque. Methods The level of plasma Lp-PLA2 was detected by chemiluminescence immunoassay in 94 patients with ACI （ACI group） and 49 healthy people（control group）. Then according to the result of carotid artery color Doppler ultrasound, the relationship of carotid artery plaque and level of plasma Lp-PLA2 was analyzed. Results The level of plasma Lp-PLA2 in ACI group was significantly higher than that in control group（P〈0. 01）. The increase in level of plasma Lp-PLA2 was in an order of unstable plaque group〉 stable plaque group 〉 non-plaque group （P〈0. 01 ）. Meanwhile, there was statistical difference in the level of plasma Lp-PLA2 between non-plaque and plaque groups （P〈0. 01 ）. Conclusion Lp-PLA2 may be, one of the independent risk factors for ACI, and the stability of carotid artery plaque can be indirectly monitored through detecting the level of plasma LIyPLA2.