变异链球菌毒力相关转录调节因子的研究进展

Development of transcriptional regulators of Streptococcus mutans in cariogenic virulence

研究发现众多转录调节因子参与调节变异链球菌耐酸性等关键致龋毒力因子的表达,虽然仍有许多转录调节因子的作用靶点和调控机制尚不明确,但已有学者针对变异链球菌个别宏观转录调控因子进行单基因突变研究。本文就已发现的影响变异链球菌致龋毒力因子表达的调节因子及其功能和可能的作用机制进行综述。

Some transcriptional regulators contribute to the expression of Streptococcus mutans （S. mutans） cariogenic virulence factors. Although the target sequence transcriptional regulators anchored on the cell wall and the molecular mecha- nism of the regulation of S. mutans are yet to be clarified, certain global regulators potentially associated with the cariogenicity of S. mutans have been identified. This review is about these related transcriptional regulators, their function, and possible mechanisms.