糖尿病对卵巢卵泡发育的影响

Impact of diabetes mellitus on ovary folliculogenesis

随着糖尿病患者数量急剧增加,女性糖尿病患者不孕不育及生殖内分泌异常疾病的问题日益严重。研究表明糖尿病患者体内的高血糖水平,异常的胰岛素浓度和瘦素浓度能够阻碍下丘脑和垂体对卵巢的调控或直接作用于卵巢影响卵泡的正常发育和卵母细胞的成熟导致排卵障碍,损伤卵巢的正常功能进而影响妊娠和内分泌稳态。本文结合最新的研究进展,深入讨论了糖尿病对卵巢卵泡发育影响的具体机制,为相关疾病的治疗提供新的思路和见解。

With the dramatic increase in the number of diabetes mellitus patients, female mellitus patients suffered infertility and reproductive endocrine disorders were becoming a serious problem. Studies have shown that in diabetes mellitus patients, the high blood sugar levels, abnormal insulin and leptin concentrations can impede the hypothalamus and pituitary regulation or directly affect the ovary to disrupt the normal folliculogenesis and oocyte maturation leading to ovulation disorders. Ovarian damage thereby affects the pregnancy and endocrine homeostasis. Here we, based on latest research progress in this area, reviewed the possible mechanisms of diabetes to ovarian follicle development, which will provide a new idea and shed light on the treatment of related diseases.