Kisspeptin对女性生殖功能调控机制的研究进展

Research progress on regulation mechanism of Kisspeptin on female reproductive function

在女性生殖活动中,kisspeptin参与调控下丘脑-垂体-性腺(HPG)轴的功能,并通过介导雌激素的正负反馈调节促性腺激素释放激素(Gn RH)的分泌,解除促性腺激素抑制激素(Gn IH)对HPG轴的负性调控作用,继而调节促性腺激素(Gn)的分泌及类固醇甾体激素的分泌,并与多种卵巢功能异常疾病的病理过程密切相关。Kisspeptin可调控卵泡发育和排卵发生,并影响子宫内膜容受性的形成。此外,在辅助生殖技术(ART)过程中kisspeptin可代替传统h CG扳机,并降低接受ART治疗的不孕症女性卵巢过度刺激综合征(OHSS)的发生。

In the complex process of female reproductive activities, kisspeptin can regulate the function of thalamus-pituitary-gonad axis （HPG） and influence the secretion of gonadotropin-releasing hormone （GnRH） through mediating estrogen negative feedback. Then it lifts negative effects of gonadotropin-inhibitory hormone （GnlH） on the HPG axis and promotes secretion of gonadotropin hormone （Gn） and steroid hormones. It is also related to pathology process of various ovarian disorders. Kisspeptin may regulate follicular growth and ovulation, and also influence the formation of endometrial receptivity. In addition, kisspeptin can replace traditional hCG trigger in assisted reproductive technology （ART） procedures, and reduce the incidence of ovarian hyperstimulation syndrome （OHSS） of those who underwent ART.