循环miR-155作为肿瘤生物标志物的研究进展

Recent Advances in Circulating miR-155 As Tumor Biomarker

microRNAs(mi RNAs)是一类在转录后水平影响生物体基因表达的小分子非编码RNA,参与调控机体正常发育和疾病发生发展等过程。新近研究发现,循环mi RNA由于具有取样方便和高度稳定性等优点,迅速成为目前的研究热点。micro RNA-155(mi R-155)在多种肿瘤中高表达。循环mi R-155已被证实与多种肿瘤的发生、发展相关,可作为一种分子标志物用于肿瘤的早期诊断和实时监测。该文围绕循环mi R-155作为肿瘤标志物的研究进展予以综述。

microRNAs （miRNAs） are a class of small non-coding RNAs that regulate gene expression through modulation of post-transcriptional activity, miRNAs have been shown to participate in the regulation of normal cellular function as well as disease development. Circulating miRNAs possess many advantages, including easy sampling and stability, miR-155 is highly expressed in various tumors, and the circulating miR-155 is aberrantly present during the tumor genesis and development. Studies have shown that circulating miR-155 could be used as a tumor marker for early diagnosis and real-time monitoring of tumors. This review discribed the recent progress of circulating miR- 155 as tumor biomarker.