活性氧在肿瘤发展和治疗中的作用

Role of Reactive Oxygen Species in Tumor Development and Therapy

活性氧(reactive oxygen species,ROS)作为机体内的一种活性分子,在细胞信号通路调节和代谢平衡方面起着重要作用。ROS能在氧化应激的条件下,参与肿瘤发生和发展过程。近年的研究表明,ROS亦可通过多种不同的作用机制诱导肿瘤细胞的死亡,且许多改变体内ROS水平的药物也逐渐进入肿瘤治疗的临床阶段。该文综述了ROS的来源及生物学意义的最新进展,重点介绍了ROS在肿瘤发生、发展中的生物学功能以及通过影响ROS水平进行肿瘤治疗的相关研究进展,以期对调控ROS水平进行肿瘤治疗的研究有所启示。

Reactive oxygen species （ROS） is a phrase used to describe a variety of molecules and free radicals （chemical species with one unpaired electron） derived from molecular oxygen. ROS are tumorigenic by virtue of their ability to increase cell proliferation, survival, migration, and also by inducing DNA damage leading to genetic lesions that initiate tumorigenicity. The growing evidence suggests that ROS can induce cellular senescence and cell death. Therefore, it can be as an anti-tumorigenic agent candidate. In this review, we gave a brief overview of recent findings of the molecular mechanism of ROS generation, discussed the roles of ROS in tumor and focused on the roles of regulation ROS level in cancer development and treatment.