千金三黄汤加味治疗膝关节骨性关节炎临床观察

Clinical Observation on Knee Osteoarthritis Treated by Qianjin Sanhuang Deocoction with Additional Integrants

目的:观察千金三黄汤加味治疗膝关节骨性关节炎的疗效及其对关节液中白介素-1(IL-1)、肿瘤坏死因子(TNF-a)的影响。方法:80例(90膝)随机分为治疗组和对照组各40例。治疗组服千金三黄汤加味,对照组口服塞来昔布胶囊。结果:总有效率治疗组82.5%,对照组60%,两组比较差异有统计学意义(P<0.05);两组WOMAC总评分、VAS总评分及膝关节液IL-1及TNF-a的含量水平测定较治疗前均下降(P<0.05)。结论:千金三黄汤加味可降低膝关节液中IL-1及TNF-a的含量,降低WOMAC总评分和VAS总评分,临床疗效显著。

Objective： To observe the clinical effect of Qianjin Sanhuang Decoction with additional integrants on knee osteoarthritis and its effect on IL-1 β and TNF-α .Method： 80 patients （90 knees ） with knee osteoarthritis were randomly divided into treatment group and control group. 40 cases were treated by Qianjin Sanhuang Decoction by oral administration as the treatment group while 40 cases were treated by celecoxib capsules by oral administration as the control group. Result： The total effective rate of the treatment group was 82.5% while that of the control group was 60%. There was statistical significance between the two groups （ P〈0.05 ） .The WOMAC score, VAS score and the content ofIL-1β and TNF- α in the knee joint fluid after the treatment decreased compared with that before the treatment. The difference was statistically significant （ P〈0.05 ） . Conclusion： Qianjin Sanhuang Decoction with additional integrants could decrease the content of IL-1 β and TNF- α in the knee joint fluid and improve WOMAC score and VAS score, with significant clinical therapeutic effect.