肿瘤异常蛋白检测的临床应用分析

Clinical application and analysis of tumor abnormal protein detection

目的用肿瘤异常蛋白(TAP)筛查恶性肿瘤,达到早期诊断和治疗的目的。方法对健康体检人群、门诊及住院患者应用TAP筛查,血液涂片加凝聚助剂处理,在光机电一体化的医疗检验仪器下观察特异图像,判定结果。结果共筛检6 669例患者标本,阳性标本为575例,阳性率为8.62%。其中体检健康人群,阳性标本5例,阳性率为0.33%;门诊患者,检出阳性标本123例,阳性率为8.01%;住院患者,阳性标本447例,阳性率为12.42%;门诊、住院患者的阳性率明显高于健康体检人群,差异有统计学意义(χ2=200.99,P<0.05)。在经临床和病理确诊的384例恶性肿瘤患者中,TAP筛查阳性检出率为81.51%,高于AFP、CEA、CA19-9、CA125、PSA 5种肿瘤标志物联合检测,差异有统计学意义(χ2=72.62,P<0.05)。结论 TAP检测用于肿瘤早期筛查、浓缩肿瘤高危人群,对肿瘤防治具有重要意义。

Objective Abnormal protein tumour（ TAP） was used to screen the malignant tumor for the early diagnosis and treatment. Methods TAP screening was performed in physical examination population,outpatients and hospitalized patients. Fingertip peripheral blood was collected and smeared on a slide with coagulant,followed by screen observation under optical- mechanical- electrical integrative equipment to assess the results. Results 6 669 samples were screened,and 575 cases were positive. The positive rate was 8. 62%. Among healthy examination population,5 cases were positive,with the positive rate of0. 33%; 123 cases were positive in outpatients,with the positive rate of 8. 01%; among the hospitalized patients,447 cases were positive,with the positive rate of 12. 42%. The positive rates for outpatients and hospitalized patients were much higher than that in the normal physical examination population,and the differences were statistically significant（ χ2= 200. 99,P〈0. 05）. Among the 384 cases of patients with clinical and pathological diagnostic malignant tumors,the positive rate of TAP screening was 81. 51%,which was much higher than the combined detection of five tumor markers（ AFP,CEA,CA19- 9,CA125 and PSA）. Therefore,the differences were statistically significant（ χ2= 72. 62,P〈0. 05）. Conclusion The clinical application of TAP screening has vital significance for the early screening of high- risk people with malignant tumor.