达那唑不同给药方式治疗复发性子宫内膜异位症效果比较

Effect observation of danazol in treating recurrent endometriosis

目的：结合临床经验,观察达那唑栓治疗复发性子宫内膜异位症的临床疗效。方法：随机选取本院妇科自2014年5月至2015年6月受手术治疗的复发性子宫内膜异位症患者68例作为研究对象,将此68例患者按照不同的用药方式分为试验组34例和对照组34例。研究组采取达那唑栓阴道或肛门给药方式治疗,对照组则采用口服达那唑胶囊方式进行治疗,两组均治疗3个月以后来医院进行妇科复诊,了解患者临床症状及妇科检查情况等,并详细记录检查结果,对比分析两组患者的临床治疗效果和不良反应。结果：研究组治疗总有效率94.1%,对照组总有效率79.4%,两组结果差异明显（P〈0.05）。两组病患治疗后的VRS评分改善程度高于治疗前,研究组的VRS评分较对照组改善更为可观,以上差异均具显著性意义（P〈0.05）。研究组不良反应发生率14.7%,对照组为35.2%,两组之前比较存在明显差异（χ^2=6.849,P=0.021）。结论：在临床治疗复发性子宫内膜异位症中运用达那唑栓阴道或肛门治疗措施,对症状及体征的改善情况较口服治疗更为可观,有效提高患者妊娠概率,且不良反应小,适于临床广泛应用。治疗效果显著优于口服治疗效果,值得推广应用。

Objectives： To observe the effect of danazol in treating recurrent endometriosis. Methods： 68 patients with recurrent endometriosis in our hospital from May 2014 to June 2015 were randomly selected. According to the different treatment,they were divided into test group and control group,with 34 cases in each group. Test group received danazol suppositories vaginal or anal drug treatment and control group received oral danazol capsule treatment. 3 months after treatment,patient＇s clinical symptoms and situation of gynaecology examination were observed. Test results were record. Clinical therapeutic effects and adverse reactions of two groups were compared.Results： Total effective rate of test group and control group was 94. 1% and 79. 4% respectively,with significant difference（ P〈0. 05）. After treatment,VRS scores of two groups were higher than these before treatment. VRS score of test group was better than that of control group,with significant difference（ P〈0. 05）. Incidence of adverse reactions in test group was 14. 7% and incidence of adverse reactions in control group was 14. 7%,with significant difference（ χ^2= 6. 849,P = 0. 021）. Conclusion： In the clinical treatment of recurrent endometriosis,the effect of danazol suppositories vaginal or anal treatment is better than that of oral group,which improves the probability of patients with pregnancy,with less adverse reaction. It is suitable for clinical application widely. Its treatment effect is significantly superior to oral therapy＇s effect,worthy of popularization and application.