沙眼衣原体与解脲支原体感染与女性不孕症相关性分析

Correlation analysis of chlamydia trachomatis and ureaplasma urealyticum infections and female infertility

目的:分析探讨沙眼衣原体(CT)与解脲支原体(UU)感染与女性不孕症之间的关系,以指导临床治疗。方法:收集我院自2013年12月至2015年6月治疗的不孕症患者235例,其中原发不孕组127例,继发不孕组108例。收集同期已生育的健康查体女性105例作为对照组。采用荧光定量PCR法进行宫颈分泌物沙眼衣原体与解脲支原体检查,并对结果进行统计学分析。结果:不孕组CT、UU及其联合感染率分别为43.4%、49.8%和13.6%,对照组感染率为10.5%、12.4%和2.9%,均有显著性差异(P<0.05)。原发不孕组CT、UU及其联合感染率分别为45.7%、46.5%和13.4%;继发不孕组CT、UU及其联合感染率分别为40.7%、53.7%和13.9%,均无显著性差异(P>0.05)。各年龄段不孕症患者感染CT、UU无显著性差异(P>0.05)。结论:沙眼衣原体与解脲支原体感染与女性不孕有一定程度的相关性,沙眼衣原体与解脲支原体检测应成为不孕症的临床常规检查项目。

Objectives： To explore the relationship between female infertility and chlamydia trachomatis and ureaplasma urealyticum infections. Methods： 235 female infertile patients who had visited our hospital from December 2013 to June 2015 were selected as infertile group,with 127 patients in primary infertile group and 108 patients with secondary infertile group. The control group consisted of 105 healthy women,who received health examination at the same period. Their cervical secretions were collected as samples used for the quantitative detection of CT and UU by means of fluorescence quantitative PCR and the results were statistically analyzed. Results： The infection rates of CT,UU and mixed infection in infertile group were 43. 4%,49. 8% and 13. 6%,which were significantly higher than these in the control group（ P〈0. 05）,which were 10. 5%,12. 4% and 2. 9%. The infection rates of CT,UU and mixed infection showed no significant difference between primary infertile group and secondary infertile group（ P〉0. 05）. The infection rates of CT and UU had no obvious difference in each age stage（ P〉0. 05）.Conclusion： There is correlation between female infertility and chlamydia trachomatisureaplasma urealyticum infections. It is necessary to detect UU,CT in the routine examinations of female infertility.