郑州市体检人群慢性肾脏病危险因素分析

Risk factors analysis of chronic kidney disease in physical examination population in Zhengzhou

目的：探讨体检人群慢性肾脏病（CKD）的危险因素。方法：搜集2013年2月至2015年5月在郑州大学第一附属医院体检科定期体检、年龄20-80岁的3 750人为研究对象,分析相关危险因素如性别、年龄、BMI、吸烟、高血压、糖尿病、高脂血症对CKD肾损伤指标的影响。结果：研究人群总体白蛋白尿检出率为8.8%（329/3 750）,肾功能减退检出率为2.8%（105/3 750）。不同性别、年龄、BMI、高血压、糖尿病、高脂血症人群白蛋白尿和肾功能减退检出率比较,差异均有统计意义（P〈0.05）;logistic回归分析显示,性别（男性）、BMI、高血压、糖尿病、高脂血症是白蛋白尿发生的独立危险因素,其OR（95%CI）分别为1.567（1.329-1.847）、1.255（1.129-1.395）、1.939（1.584-2.372）、2.370（1.888-2.975）、1.293（1.099-1.521）;年龄、高血压、糖尿病、高脂血症是肾功能减退的独立危险因素,其OR（95%CI）分别为1.970（1.379-2.814）、1.654（1.218-2.245）、1.394（1.072-1.812）、1.929（1.369-2.718）。结论：早期识别体检人群中增加CKD风险的危险因素,并积极及时给予综合防治,对于降低CKD发病率、规范CKD健康管理具有非常重要的意义。

Aim： To discuss the risk factors of chronic kidney disease（ CKD） in physical examination population in Zhengzhou. Methods： A total of 3 750 cases of physical examination population,aged 20 to 80 years,who accepted regular medical checkup in the First Affiliated Hospital of Zhengzhou University between February 2013 to May 2015 were collected as the research objects. Relevant risk factors,such as gender,age,BMI,smoking,hypertension,diabetes and hyperlipemia were analyzed. Results： The overall albumin urine detection rate was 8. 8%（ 329 /3 750）,renal function decrease detection rate was 2. 8%（ 105 /3 750）. There were significant differences in albumin urine detection rate and renal function decrease detection rate between different gender,age,BMI,hypertension,diabetes,or hyperlipidemia groups（ P〈0. 05）.Multiple logistic regression analysis showed that gender（ male）,BMI,hypertension,diabetes,and hyperlipidemia were independent risk factors for the development of albuminuria,the OR（ 95% CI） were 1. 567（ 1. 329- 1. 847）,1. 255（ 1. 129- 1. 395）,1. 939（ 1. 584- 2. 372）,2. 370（ 1. 888- 2. 975）,1. 293（ 1. 099- 1. 521）,respectively; age,hypertension,diabetes,and hyperlipidemia were independent risk factor for renal function decrease,and the OR（ 95% CI） were1. 970（ 1. 379- 2. 814）,1. 654（ 1. 218- 2. 245）,1. 394（ 1. 072- 1. 812）,1. 929（ 1. 369- 2. 718）,respectively. Conclusion： Early recognition the risk factors that could increase the risk of CKD in physical examination crowd,and taking measures to comprehensive prevent and cure,which is of great value of reducing the incidence and standardizing health management of CKD.