缺氧诱导因子1在肿瘤细胞免疫逃避中的作用（英文）

Role of hypoxia-inducible factor-1 in immune escape of tumor cells

缺氧是肿瘤的重要特征。在肿瘤发生过程中,缺氧诱导因子1是协调缺氧变化的重要的调节因子。缺氧和缺氧诱导因子1可以调节肿瘤内的免疫应答,缺氧通过激活缺氧诱导因子1及其下游信号通路诱导肿瘤细胞产生多种机制以逃避免疫系统的识别和攻击。作者主要综述了缺氧诱导因子1介导的肿瘤免疫逃避,以及针对缺氧诱导因子1靶向药物的开发。

Hypoxia is a hallmark of tumor,and hypoxia-inducible factor（ HIF-1） is an essential regulator of hypoxia adaptation in tumor progression. Hypoxia and HIF-1 signaling are important components of the tumor microenvironment that modulates the tumor immune response. Tumor hypoxia via HIF-1 signaling enables tumor cell to develop mechanisms to evade from immune surveillance and attack. This mini-review emphasizes on the molecular mechanisms of HIF-1-mediated tumor cell escape and the development of inhibitors targeting HIF-1.