左旋氨氯地平对脑梗死合并高血压患者颈内血管功能的影响

Effect of Levo-amlodipine on Internal Carotid Artery Function in Cerebral-infarcted Patients Combined with Mild Hypertension

目的观察左旋氨氯地平对脑梗死合并轻度高血压患者颈内动脉血管功能的治疗效果。方法将82例颈内动脉系统脑梗死并轻度高血压患者,随机分为治疗组42例和对照组40例。在相同的危险因素下,治疗组和对照组每天分别使用左旋氨氯地平2.5 mg和氨氯地平5 mg治疗1年。观察患者的血压、颈内动脉内膜厚度、狭窄支数、副作用等指标。结果治疗后,各组中血压、颈内动脉厚度、狭窄支数与治疗前比较,差异有统计学意义(P<0.01)。两组间治疗前后,血压、颈内动脉内膜和狭窄支数比较,差异无统计学意义(P>0.05);但两组间副反应比较差异有统计学意义(P<0.05)。结论左旋氨氯地平可以降低患者血压,并有抗颈内动脉粥样硬化和改善血管功能的作用。

OBJECTIVE To study the effect of levo-amlodipine on internal carotid artery function in patients with cerebral infarction combined with mild hypertension. METHODS 82 patients with internal carotid artery cerebral infarction combined with mild hypertension were randomly divided into treatment group（ n = 42）and control group（ n = 40）. Levo-amlodipine tablets 2.5mg/d orally and amlodipine tablets 5mg/d orally were given for 1 year for the group of treatment and control respectively. The blood pressure, carotid artery intima -media thickness（ IMT）, number of internal carotid artery narrow and side effects were evaluated. RESULTS Compared with those of pre-treatment, blood pressure, IMT, number of internal carotid artery narrow were significantly different （ P〈0.01 ） in those of post-treatment. There were no significant difference between groups of（P〉0.05）pre-treatment and post-treatment, while side effects were observed significantly different between the two groups （ P 〈 0.05 ）. CONCLUSION Levo-amlodipine had effect of anti- hypertension and anti-internal carotid artery atherosclerosis, as well as vessel function improvement.