脂质体肝靶向递药系统及其在肝脏疾病中的研究进展

Liver-targeting liposome drug delivery system and its research progress in liver diseases

脂质体靶向治疗主要分为主动靶向、被动靶向及物理化学靶向.在脂质体肝靶向方面,主动肝靶向脂质体以其专一性逐渐受到关注,可用于肝纤维化、肝炎等多种肝脏疾病,尤其对于慢性肝脏疾病.同时,粒径可控制脂质体的被动肝靶向,而物理化学肝靶向脂质体对治疗肝癌有一定优势.本文主要以近年来国内外的文献为依据进行了阐述和分析.

Liposome-based targeted therapy is mainly divided into active targeting, passive targeting, and physical and chemical targeting. In terms of liver targeting, because of specificity, active liver-targeting liposomes have received more and more attention, and these types of liposomes can be used in liver fi brosis, hepatitis and other chronic liver diseases. In addition, the particle size could control the passive liver targeting of liposomes, while the liver-targeted liposomes of the physical and chemical targeting type have advantages in treating hepatic carcinoma. In this paper, we focus on the basics and application of liver-targeting liposome drug delivery system in hepatic diseases.