婴幼儿细菌性肺炎合并腹泻治疗方法及对免疫细胞的影响

Treatment of infants with bacterial pneumonia and diarrhea: Clinical effi cacy and impact on immune cells

目的观察婴幼儿细菌性肺炎合并腹泻治疗方法及对免疫细胞的影响,为临床提供依据.方法选取2015-01/2016-07诊治的婴幼儿细菌性肺炎合并腹泻患儿60例,根据治疗方案不同分为对照组(n=30)和观察组(n=30).对照组采用乳酸菌片治疗,观察组联合思密达治疗,采用流式细胞仪检测免疫指标,比较2组临床疗效及对细胞免疫的影响.结果观察组治疗7 d疗效率显著高于对照组(93.33%v s 70.00%,P<0.05);观察组大便次数正常、大便性状正常、实验室指标正常及临床症状消失时间,显著短于对照组(P<0.05);观察组治疗后细胞免疫功能水平Ig M、Ig G及Ig A,显著高于对照组(P<0.05).结论婴幼儿细菌性肺炎合并腹泻患儿在乳酸菌片基础上联合思密达治疗效果理想,能提高患儿T淋巴细胞亚群水平,值得推广应用.

AIM To evaluate the effi cacy of different treatments in infants with bacterial pneumonia and diarrhea and their impact on immune cells. METHODS From January 2015 to July 2016 60 infants with bacterial pneumonia and diarrhea treated at our hospital were divided into either a control group（n=30） or an observation group（n=30）. The control group was treated with lactobacillus tablets and the observation group was treated with lactobacillus tablets combined with Smecta. Flow cytometry was used to determine immune indexes. Clinical efficacy and immunity were compared between the two groups. RESULTS After 7d of treatment the effective rate was signifi cantly higher in the observation group than in the control group（93.33% vs 70.00% P〈0.05）. Times to recovery of normal stool frequency normal stool characters normal laboratory values and disappearance of clinical symptoms were signifi cantly shorter in the observation group than in the control g r o u p（ P〈0. 0 5）. Thelevels of IgMI g G and Ig A were significantly higher in the observation group than in the control group（P〈0.05）. CONCLUSION For infants with bacterial pneumonia complicated by diarrhea lactobacillus tablets combined with Smectacan improve the immune levels and have good effi cacy.