OPN、B7-H4在上皮性卵巢癌患者血清中的表达及临床意义

Clinical significance and expression of OPN and B7-H4 in serum of patients with epithelial ovarian cancer

目的观察骨桥蛋白(OPN)、B7-H4在上皮性卵巢癌患者血清中的表达,并探讨其对肿瘤良恶性的鉴别价值。方法选取2013年2月至2015年12月在我院接受治疗的100例上皮性卵巢癌患者为观察对象,同时选取100例卵巢良性肿瘤的患者、100例健康成年女性为对照。观察不同组别OPN、B7-H4及肿瘤标志物水平的差异,比较不同临床病理特征的患者OPN、B7-H4水平的差异。结果上皮性卵巢癌组的OPN、B7-H4阳性表达率高于卵巢良性肿瘤组和健康对照组;3组血清CEA、CA15-3和CA125水平由高到低分别为上皮性卵巢癌组、卵巢良性肿瘤组和健康对照组,差异具有统计学意义(P<0.05);Ⅲ+Ⅳ期、低分化、有淋巴结转移的上皮性卵巢癌患者的OPN、B7-H4表达率较高,差异具有统计学意义(P<0.05),而不同年龄的患者其OPN、B7-H4表达率差异无统计学意义(P>0.05)。结论 OPN、B7-H4在上皮性卵巢癌中高表达,且低分化、转移的患者其OPN、B7-H4阳性表达率更高。

Objective To observe the expression of osteopontin（OPN） and B7-H4 in epithelial ovarian cancer, and to explore the differential diagnosis of benign and malignant value. Methods A total of 100 patients with epithelial ovarian cancer who were treated in our hospital from February 2013 to December 2015 were selected as the study subjects, 100 patients with benign ovarian tumor and 100 healthy controls were selected as the control groups. The differences of OPN, B7-H4 and tumor marker levels in different groups were observed, and the differences of OPN and B7-H4 levels in patients with different clinical pathological characteristics were compared. Results The positive expression rate of OPN and B7-H4 in epithelial ovarian cancer group was higher than those in benign ovarian tumor group and healthy control group. The levels of CEA,CA15-3 and CA125 in serum of the three groups from high to low were epithelial ovarian cancer group,benign ovar- ian tumor group and healthy control group, the differences were statistically significant （P 〈 0.05）. Stage III and IV,low differentiation, lymph node metastasis of epithelial ovarian cancer patients of OPN and BT-H4 expression rate was higher, and the difference was statistically signifi- cant （ P 〈 0.05）. The expression rate of OPN and B7-H4 in different age patients had no significant difference （P 〉 0.05）. Conclusion B7- H4 and OPN are highly expressed in epithelial ovarian cancer,and the expression rate of OPN and B7-H4 is higher in the patients with low differentiation and metastasis.