石松生物碱和三萜成分的分离与鉴定

Alkaloids and Triterpenoids from Lycopodium japonicum

云南宣威产石松(Lycopodium japonicum)干燥全草用甲醇提取,利用硅胶柱层析和Sephadex LH-20柱层析进行化学成分分离纯化,从中分离得到12个生物碱和3个三萜化合物,根据现代波谱技术和理化性质对化合物结构进行鉴定,鉴定结构为:lycodoline(1),acetyllycoposerramine M(2),lycoposerramine-M(3),6α-hydroxylycopodine(4),12-epilycodoline(5),12β-hydroxy-acetylfawcettiine(6),lucidioline(7),α-obscurine(8),des-N-methyl-α-obscurine(9),lycopoclavamine-A(10),fawcettimine(11),lycoflexine N-oxide(12),α-onocerin(13),26-nor-8-oxo-α-onocerin(14)和diepiserratenediol(15).化合物4、5、12和15为首次从石松中分离得到.

Fifteen compounds including twelve alkaloids, and three triterpenoids were isolated from the whole plants of Lycopodium japonicum Thunb, and their structures were elucidated as lycodoline（1）, acetyllycoposerramine M（2）, lycoposerramine-M（3）, 6α-hydroxylycopodine（4）, 12-epilycodoline（5）, 12β-hydroxy-acetylfawcettiine（6）, lucidioline（7）, α-obscurine（8）, des-N-methyl-α-obscurine（9）, lycopoclavamine-A（10）, fawcettimine（11）, lycoflexine N-oxide（12）, α-onocerin（13）, 26-nor-8-oxo-α-onocerin（14） and diepiserratenediol（15） respectively. Compounds 4、5、12 and 15 were isolated from L. japonicum for the first time.