一种多手性中心氨基醇化合物的合成

Synthesis of Amino Alcohols Containing Multiple Stereogenic Centers

手性氨基醇结构广泛存在于天然产物和药物分子中,普遍具有良好的生物活性;同时该类化合物在不对称催化研究中也是一类重要的手性配体,因此手性氨基醇的合成研究具有重要的意义.文章合成了一种多手性中心氨基醇化合物.该化合物不仅具有刚性较大的环丙烷结构,并且具有多个手性中心,可应用于药理学筛选和不对称催化研究.

Chiral amino alcohols widely exist in natural products and drugs, and generally have good biological activity.These compounds are also an important class of chiral ligands in asymmetric catalysis. So it is important to study the synthesis of chiral amino alcohols. In this paper, two amino alcohol compounds containing multiple stereogenic centers have been synthesized. These compounds have cyclopropane structure with greater rigidity and multiple stereogenic centers. It can be used in pharmacology screening studies and asymmetric catalysis.