右美托咪定对学龄前儿童术后躁动及认知功能的影响

目的研究右美托咪定对学龄前儿童术后躁动及认知功能的影响。方法选择全身麻醉手术小儿60例，年龄5-6周岁，ASAⅠ-Ⅱ级，心肺功能未见异常，对药物试验无过敏者。随机分为观察组（D组）和对照组（C组）。观察组给予右美托咪定0．8μg／（kg·h）输注10min，并于0．5μg／（kg·h）术中维持至手术结束前30min停止，对照纽输注同等计量的0．9％氯化钠溶液。对两组患儿进行苏醒期Ramsay镇静评分。并分别在术后前3d进行学习记忆功能测定。结果观察组患儿在苏醒期Ramsay镇静评分明显优于对照组，且术后前3d的认知功能优于对照组。结论一定剂量的右美托咪定可以明显降低学龄前儿童术后苏醒期躁动的发生率且改善学龄前儿童术后短期的认知功能。

Objective To explore the effect of dexmedetomidine on preschool children postoperative agitation and cognitive function. Methods 60 cases of general anesthesia in children aged 5-6 years of age were enrolled, they wereof ASA Ⅰ - Ⅱgrade, with no abnormal heart and lung function, no drug allergy test. They were randomly divided into two groups： the experimental group （ group D ） and control group （ group C ） . Experimental group were given dextromethorphan ethyl set 0.8 μ g / （ kg.h ） infusion 10min, and maintained until the end of operation 30min stop, control infusion equivalent of 0.9% measured in chloride 0.5 μ g / （ kg.h ） surgery sodium. Two groups of children were evaluated with Ramsay sedation score during wake period. And learning and memory function were measured before surgery three days. Results In the wake of the children in the experimental group Ramsay sedation scores were significantly lower than the control group. Three days before and after cognitive function than the control group. Conclusions Dose of dexmedetomidine given preschoolers can significantly reduce the postoperative incidence of restlessness and improved short-term postoperative cognitive function in preschool children.