219株铜绿假单胞菌临床分布和耐药性分析

目的了解铜绿假单胞菌的临床分布及耐药情况，为临床合理用药提供依据。方法采用Microscan auto SCAN-4细菌鉴定分析仪，对2014年1月至2015年12月检出的219株铜绿假单胞菌进行鉴定及药敏分析。结果219株铜绿假单胞菌主要来源于痰标本和脓液标本，痰标本检出173株，占79．00％；脓液标本检出19株，占8．68％；219株铜绿假单胞菌主要来自本院各病区住院患者，科室分布以ICU、呼吸内科和老年病科为主，分别占22．37％、17．35％和13．24％；抗菌药物中氨曲南的耐药率最高，耐药率为51．2％，耐药率最低的抗菌药物是阿米卡星，耐药率13．2％。结论铜绿假单胞菌引起的感染以下呼吸道为主，临床医师应根据药敏试验结果合理使用抗菌药物，减少耐菌株的产生。

Objective To investigate clinical distribution and the drug resistance of Pseudomonas aeruginosa, to provide scientific evidences for clinical application of antibiotic. Methods We retrospectively surveyed the infection of Pseudomonas aeruginosa in our hospital from January 2014 to December 2015, Mierosean auto SCAN-4 was used to identify the separation of 219 strains Pseudomonas aeruginosa drug susceptibility results analyzed. Results 219 strains Pseudomonas aeruginosa were mainly isolated from sputum and pus specimens, 173 strains were isolated from sputum specimens, accounted 79.00 % ; 19 strains were isolated from pus specimens, accounted 8.68 %, 219 strains Pseudomonas aeruginosa were mainly isolated from patients hospitalized in the intensive care unit （ ICU ） （ 22.37% ） , which were mainly from Respiratory Medicine Department of Gastroenterology （ 17.35% ） and Department of geriatrics （ 13.24% ） , the most resistance rates was azatreonam （ 51.2% ） , the lowest resistance rates was amikasin （13.2%） .Conclusions Pseudomonas aeruginosa mostly come from lower respiratory tract infection specimen, soclinicaldoctors should select antimicrobials according to drug susceptibility test.