火针四花穴对非小细胞肺癌化疗患者临床疗效及MMP-9、TIMP-1的影响

Influence of Fire Needling on Sihua Acupoints on Contents of MMP-9 and TIMP-1 in Serum with Chemotherapy Patients with Non-Small-Cell Lung Cancer

目的:观察火针四花穴对非小细胞肺癌化疗患者临床疗效,并通过检测血清中MMP-9、TIMP-1的含量探讨其可能机制。方法:将60例非小细胞肺癌患者随机分为观察组与对照组,各30例。对照组给予常规化疗(采用TP,GP,DP,AP方案化疗),观察组在常规化疗的基础上给予火针四花穴(膈俞、胆俞),治疗21 d。在治疗后采用RECIST标准进行肿瘤客观指标评定,并分别在治疗前后检测患者血清中MMP-9、TIMP-1的含量。结果:治疗后观察组有效率(ORR)为20.00%,稳定率(OSD)为73.33%,与对照组比较,差异无统计学意义(P>0.05);治疗后患者血清中MMP-9、TIMP-1含量,观察组高于对照组,差异具有统计学意义(P<0.05)。同时MMP-9与TIMP-1相关性系数r=0.913,二者显著正相关(P<0.01);MMP-9与RECIST评价相关性系数r=0.764,二者显著性相关(P<0.01);TIMP-1与RECIST评价相关性系数r=0.894,二者显著性相关(P<0.01)。结论:火针四花穴对非小细胞肺癌化疗患者具有稳定肿瘤的作用,可能通过降低血清中MMP-9、TIMP-1含量来影响肿瘤的侵袭、转移。非小细胞肺癌患者血清中MMP-9、TIMP-1水平与患者RECIST评价具有一致性,可反映非小细胞肺癌患者预后情况。

Objective：To observe the clinical efficacy of fire needling on Sihua acupoints onnon - small cell lung cancer patients with chemotherapy and through the detection of serum contents of MMP -9 and TIMP - 1 to explore its possible mechanism. Methods ： Sixty cases of non - small cell lung cancer patients were randomly divided into observation group and control group. Among them, patients （ n = 30） were given chemotherapy （ TP, GP, DP, AP） in control group. Meanwhile, in the observation group （ n = 30）, patients were given fire needling on Sihua acupoints [ Geshu （ BL 17 ）, Danshu （BL19） ] on the basis of chemotherapy. After treatment, evaluate tumor objective indicators and evaluate with RECIST. Respectively, the serum contents of MMP -9 and TIMP - 1 were detected before and after treatment in patients. Results：In observation group,the ORR rate was 20.00% and OSD rate was 73.33 %. However, compared with the control group, there was no statistically significant difference in ORR rate or OSD rate. Compared with the control group, the contents of MMP -9 and TIMP - 1 in serum were higher in observation group （P〈0. 05）. At the same time,the correlation coefficient（r） between MMP -9 and TIMP - 1 was 0. 913（P 〈0; 01 ）. The correla- tion coefficient（r） between MMP - 9 and RECIST was 0.764 （ P 〈 O. 01 ） and the correlation coefficient（r） between MMP - 9 and RECIST was 0. 894 （P 〈 0.01 ）. Conclusion：Fire needling on Sihua acupoints can have an effect fo keep tumor stable with chemotherapy patients with non - small - cell lung cancer,it may reduce the contents of MMP -9 and TIMP - 1 in serum to affect tumor invasion and metastasis. In non - small cell lung cancer patients, the contents of MMP - 9 and TIMP - 1 in serum have consistency with RECIST. Therefore they can reflect the prognosis of patients with non - small cell lung cancer.