降钙素原和淀粉样蛋白A在乳腺癌患者手术切口感染中的诊断价值

Diagnostic values of calcitonin and amyloid A in incision infection of patients with breast cancer

目的探讨降钙素原和淀粉样蛋白A在乳腺癌患者手术切口感染中的诊断价值。方法收集2013年1月-2016年6月浙江省肿瘤医院乳腺外科和浙江大学附属第二医院肿瘤外科收治的乳腺癌切除术患者456例，根据患者术后是否发生切口感染，将患者分为感染组和非感染组，其中感染组23例，非感染组433例。比较两组患者降钙素原、淀粉样蛋白A、C反应蛋白、白细胞和白蛋白水平。结果与非感染组比较，感染组患者降钙素原显著增加（P=0．000），淀粉样蛋白A显著增加（P=0．000），C反应蛋白显著增加（P=0．000），白细胞显著增加（P=0．000）。两组患者白蛋白水平比较，差异无统计学意义（P〉0．05）。ROC曲线显示降钙素原、淀粉样蛋白A、C反应蛋白和白细胞在预测乳腺癌患者术后切口感染中的曲线下面积分别为0．858（0．731-0．979）、0．866（0．772-0．959）、0．682（0．552-0．812）和0．678（0．566-0．790），两组比较，差异有统计学意义（P〈0．05）。结论降钙素原和淀粉样蛋白A在预测乳腺痛患者术后切口感染中具有较好的应用价值。

Objective To explore the diagnostic values of calcitonin and amyloid A in incision infection of patients with breast cancer. Methods A total of 456 patients undergoing breast cancer surgery in Department of Breast Surgery in Zhejiang Cancer Hospital and Department of Oncological Surgery in the Second Affiliated Hospital of Zhejiang University from January 2013 to June 2016 were collected, then the eases were divided into infection group （23 cases） and non-infection group （433 cases） according to occurrence of incision infection or not. The levels of calcitonin, amyloid protein A, C-reactive protein, white blood cell count, and albumin in the two groups were compared. Results Compared with non-infection group, the levels of ealcitonin, amyloid protein A, C-reactive protein, and white blood cell count in infection group increased significantly （ P = 0. 000, P = 0. 000, P = 0. 000, P = 0. 000） . There was no statistically significant difference in the level of albumin between the two groups （ P〉0. 05 ） . The areas under receiver operating characteristic curve of caleitonin, amyloid protein A, C-reactive protein, and white blood cell count in prediction of incision infection were 0. 858 （0. 731-0. 979）, 0. 866 （0. 772-0. 959）, 0. 682 （0. 552-0. 812）, and 0. 678 （0. 566-0. 790）, respectively, there was statistically significant difference between the two groups （P〈 0. 05） . Conclusion The application value of ealcitonin and amyloid protein A in prediction of incision infection of patients with breast cancer is good.