CA125、CEA、CA724和P53检测诊断非小细胞肺癌脑转移的价值分析

Value of CA125,CEA,CA724 and P53 Expressions in diagnosis of NSCLC with Brain Metastases

目的探讨CA125、CEA、CA724和P53表达对非小细胞肺癌患者脑转移的诊断价值。方法选取2013年2月-2016年1月收治的非小细胞肺癌患者82例为观察对象,其中发生脑转移的41例设为转移组,未发生41例设为未转移组。分别测定所有患者血清中的CA125、CEA、CA724和P53表达。同时计算CA125+CEA、CA125+CEA+CA724以及四项联合检测非小细胞肺癌患者脑转移的灵敏度、特异性、准确度及阳性率与病理结果进行比较。结果转移组CEA浓度显著高于未转移组;CA125、CEA、CA724和P53表达在转移组中的阳性率均显著高于未转移组;以病理检测结果为标准,CA125+CEA、CA125+CEA+CA724、四项联合这三种检测结果中阳性、阴性比例逐渐升高,假阳性、假阴性比例逐渐下降,四项联合检测灵敏度、特异性以及准确度显著高于CA125+CEA、CA125+CEA+CA724检测。结论 CA125、CEA、CA724和P53联合检测对非小细胞肺癌患者脑转移具有更高的参考价值,值得临床应用。

Objective To study the expressions of CA125, CEA, CA724 and P53 in the diagnosis of brain metasta- ses of non - small cell lung cancer （ NSCLC ） patients. Methods 82 NSCLC patients treated in our hospital from February 2013 to January 2016 were included in the study. Among them, 41 cases with the occurrence of brain metastases were set as metastases group and the other 41 cases as non -metastases group. CA125, CEA and CA724 and P53 expressions in all pa- tients＇ serums were measured. MeanMlile, the sensitivity, specificity, accuracy, and positive rate of brain metastases in NSCLC patients were calculated by CA125 ＋ CEA, CA125 ＋ CEA ＋ CA724, and CA125 ＋ CEA ＋ CA724 ＋ P52 respectively. The results were compared with the pathologic findings. Results The concentration of CEA in the metastases group was sig- nificantly higher than that in the non -metastases group. The positive rates of CA125, CEA, CA724 and P53 expressions in the metastases group were significantly higher than those in the non - metastases group. In contrast with the pathological test results as the standard, the proportions of positive and negative rates of CA125 ＋ CEA, CEA ＋ CA125 ＋ CA724 and CA125 ＋ CEA ＋ CA724 ＋ 1752 were increased gradually, and the proportions of false - positive and false - negative were decreased gradually. Sensitivity, specificity and accuracy detected by four expressions jointly were significantly higher than those of oth- er two kinds of detection. Conclusion The joint detection of CA125, CEA, CA724 and P53 in NSCLC patients with brain metastases has a higher reference value, which is worthy of clinical application.