角质细胞生长因子-2有关呼吸系统的研究进展

Research progress of keratinocyte growth factor-2 in respiratory system

吸入性损伤、慢性阻塞性肺疾病（COPD）等呼吸系统疾病的本质多为急性肺损伤（ALI）或组织器官发育不良。目前治疗上除对症支持治疗外，尚缺乏针对ALI损伤修复及相关疾病发生机制方面的治疗手段。角质细胞生长因子-2（KGF-2）广泛存在于气道、肺组织，对组织器官发育、维持肺稳态具有重要意义。KGF-2表达异常可诱发COPD，甚至可导致早产儿并发支气管肺发育不良；同时，KGF-2能减轻肺部炎症反应，促进Ⅱ型肺泡上皮细胞增殖，修复受损的肺泡上皮，对铜绿假单胞菌肺炎及ALI具有修复治疗作用，为KGF-2进一步治疗吸入性损伤奠定了基础。现就KGF-2对呼吸系统的组织器官发育、损伤修复及疾病治疗等方面的研究进展进行综述。

The essence of inhalation injury, chronic obstructive pulmonary disease （COPD） and other respiratory diseases is the acute lung injury （ALI） or the poor development of tissue and organ. At present, there is a lack of treatment for ALI and the pathogenesis of the disease except symptomatic supportive treatment. Keratinocyte growth factor-2 （KGF-2） widely exists in the airway, lung tissue, and is significantly important to maintain steady development of lung tissues and organs; at the same time, the abnormal expression of KGF-2 can induce COPD, and can even lead to prcmature infants with bronchopulmonary dysplasia. It was found in this study that KGF-2 can reduce lung inflammation, promote the proliferation of alveolar type Ⅱ epithelial cells, repair the damage of alveolar epithelial cell, and is effective in the restoration treatment of Pseudomonas aeruginosa pneumonia and ALI, which laid the foundation of the further study of KGF-2 treatment for inhalation injury. The research progress of KGF-2 in the development of respiratory system, injury repair and disease treatment were reviewed in this article.