左炔诺孕酮宫内缓释系统治疗子宫内膜异位症的临床效果观察

Observation on the Clinical Effect of Levonorgestrel Intrauterine Sustained-release System in Treatment of Endometriosis

目的观察左炔诺孕酮宫内缓释系统治疗子宫内膜异位症的临床效果。方法选取我院收治的子宫内膜异位症患者84例,采取数字随机法分成观察组和对照组,观察组采取左炔诺孕酮宫内缓释系统治疗,对照组采取常规治疗,比较两组临床效果。结果观察组总有效率97.62%,对照组总有效率78.57%,观察组患者总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者TIMP-1、MMP-9水平均低于对照组,差异均有统计学意义(P<0.05)。结论左炔诺孕酮宫内缓释系统治疗子宫内膜异位症的临床效果较米非司酮更好,并且用药安全,是有效的药物治疗方法之一。

Objective To observe the clinical effect of levonorgestrel intrauterine sustained-release system in the treatment of endometriosis. MethodsEighty-four patients with endometriosis were divided into observation group and control group by digital randomization method. The observation group was treated with levonorgestrel intrauterine sustained-release system,and the control group was treated with conventional therapy. Compared the clinical effects. Results The total effective rate was 97.62% in the observation group and 78.57% in the control group. The total effective rate in the observation group was significantly higher than that in the control group（P〈0.05）. The levels of TIMP-1 and MMP-9 in the observation group were lower than those in the control group,the difference was statistically significant（P〈0.05）. Conclusion Levonorgestrel intrauterine sustained-release system is more effective than mifepristone in the treatment of endometriosis. It is an effective drug therapy.