胱抑素C在早期肾功能损伤中的诊断价值

The Diagnostic Value of Cystatin C in the Early Renal Injury

目的探讨胱抑素C(Cys-C)在早期肾功能损伤中的诊断价值。方法选取160例肾脏疾病患者,根据尿常规定性检测结果将其分成3组,尿蛋白阴性组53例,微量尿蛋白组57例,大量尿蛋白组50例,收集健康体检人群50例为对照组。结果尿蛋白阴性组、微量尿蛋白组、大量尿蛋白组、对照组的Cys-C水平比较,差异均有统计学意义(P<0.05);大量尿蛋白组肌酐、尿素氮水平高于对照组、尿蛋白阴性组、微量尿蛋白组(P<0.05),对照组、尿蛋白阴性组、微量尿蛋白组肌酐、尿素氮水平比较,差异无统计学意义(P>0.05)。结论 Cys-C是诊断早期肾功能损伤的可靠方法。

Objective To investigate the serum cystatin C（Cys-C）in the diagnosis of early renal injury. Methods 160 cases of kidney disease were selected, according to the results of routine urine test, the results were divided into 3 groups, Urine protein negative group of 53 cases, trace urinary protein group of 57 cases, a large number of urinary protein group of 50 cases, 50 cases of healthy people were collected as control group. Results Cys-C levels in urine protein negative group、urinary protein group、a large number of urinary protein group and control group compared, the difference was statistically significant（P〈0.05）. The levels of serum creatinine and urea nitrogen in a large number of urinary protein group were significantly higher than those of control group, urine protein negative group and urinary protein group（P〈0.05）. The levels of serum creatinine and urea nitrogen in control group、 urine protein negative group and trace urinary protein group compared, the difference was no statistical significance（P〈0.05）.Conclusion Cys-C is a reliable method for diagnosis of early renal function injury.