下呼吸道肺炎克雷伯菌ESBLs的检测及耐药性分析

Detection and Drug Resistance Analysis of Klebsiella Pneumoniae ESBLs in Lower Respiratory Tract

目的研究下呼吸道肺炎克雷伯菌ESBLs的检测和耐药性。方法收集2014年4月~2016年1月的120例经细菌鉴定和药敏实验分析确定的肺炎克雷伯菌标本作为研究对象,采用仪器法和双纸片协同对ESBLs进行检验。结果重症监护病房的肺炎克雷伯菌检出率为15.36%,感染科检出率为8.02%,其感染部位主要是以患者的呼吸道为主,占38.60%。本研究120株肺炎克雷伯菌标本共检测出ESBL阳性40株,阳性率为33.33%。结论 ESBLs是肺炎克雷伯菌产生的β-内酰胺酶中的一种,且产酶菌株的耐药率高于非产酶菌株,对于ESBLs的检测十分重要,需要在临床上进行强化。

Objective To study the detection and drug resistance of Klebsiella pneumoniae ESBLs in the lower respiratory tract. Methods Selected 120 cases collected from April 2014 to January 2016 by the bacterial identification and susceptibility testing analysis of Klebsiella pneumoniae were used as the research objects,using the instrument method and double disk synergy test on ESBLs. Results The detection rate of Klebsiella pneumoniae in intensive care unit was 15.36%,the infection rate was 8.02%, the infection site was mainly in patients with respiratory tract,accounting for 38.60%. In this study,120 strains of Klebsiella pneumoniae were detected. The positive rate of ESBL was 40,and the positive rate was 33.33%. Conclusion ESBLs is a kind of beta- produced by Klebsiella pneumoniae,and the rate of enzyme production is higher than that of non enzyme producing strains,and the detection of ESBLs is very important, which needs to be strengthened in clinical practice.