血清胱抑素C与乙型肝炎性肝硬化肝功能损害程度的相关性分析

Correlation Analysis of Serum Cystatin Level and Liver Function Damage in Patients with Posthepatitic B Cirrhosis

目的:探讨血清胱抑素C(Cys C)与乙型肝炎性肝硬化患者肝功能损伤程度的相关性分析。方法:将98例乙型肝炎性肝硬化患者按照肝功能分级的Child-Pugh评分将分为A组(Child A级,n=45例)、B组(Child B级,n=33例)、C组(Child C级,n=20例),同期选取本院门诊正常健康体检者为对照组,检测所有受试者的血清Cys C水平,比较各种之间相关指标的差异。结果:A组、B组、C组、对照组丙氨酸氨基转移酶(ALT)、天门冬氨酸转移酶(AST)、血清白蛋白(ALB)、血清Cys C及血清Cys C阳性率均有统计学差异(P<0.05),C组血清Cys C、血清Cys C阳性率高于对照组(P<0.05)、A组、B组,而B组高于对照组、A组(P<0.05);血清Cys C阳性组与阴性组中含有Child A级、Child B级、Child C级患者的构成比具有统计学意义(P<0.05),Cys C阳性组中的Child C级患者比例高于阴性组(P<0.05);血清Cys C与Child-Pugh评分呈正相关(P<0.05);Child-Pugh评分、ALT、AST与患者血清Cys C阳性呈正相关(P<0.05);而ALB则与其呈负相关(P<0.05);结论:乙型肝炎性肝硬化患者血清Cys C水平与肝功能损伤程度呈一定相关性,早期检测血清Cys C水平对于评估乙型肝炎性肝硬化患者的肝功能损害具有一定的临床意义。

Objective： To investigate the correlation of serum cystatin（Cys C） level and liver function damage in patients with posthepatitic B cirrhosis. Methods： 98 patients with hepatitis B cirrhosis liver function according to the classification of the Child-Pugh score will be divided into group A（Child class A, n=45） and group B（Child class B, n=33）, group C（Child class C, n=20）. At the same time, the healthy peoples having normal physical examination in our hospital clinic were selected as control. Detect serum Cys C level of all subjects, and compare the differences in various relevant indicators between groups. Results： The levels of alanine aminotransferase（ALT）,aspartate transaminase（AST）（propagated）, serum albumin, serum Cys C and positive rate of serum Cys C had statistical difference between group A, B, C and the control group（P〈0.05）. The serum Cys C level and its positive rate of group C were the highest among the groups（P〈0.05）, and those of group B were higher than those of the control group and group A（P〈0.05）. In the serum Cys C positive group, the constituent ratio of patients with Child class A, B and C was statistically different with that in the serum Cys C negative group（P〈0.05）. The percentage of patients with Child class C was higher in Cys C positive group than in negative group（P〈0.05）. Serum Cys C levels were positively correlated with the Child-Pugh scores（P〈0.05）. The Child-Pugh score, levels of ALT and AST were positively correlated with the positive serum Cys C（P〈0.05）, while ALB level was negatively correlated with it（P〈0.05）. Conclusion： The serum Cys C level of hepatitis B cirrhosis patients had a correlation with the liver function damage degree. Early detection of serum Cys C level has a certain clinical significance in evaluating liver function damage of hepatitis B patients with liver cirrhosis.