摘要
目的：探讨血清癌胚抗原（CEA）、糖类癌抗原199（CA19—9）、糖类癌抗原724（CA72—4）、糖类癌抗原242（CA242）等4项肿瘤标志物联合检测在不同肠道疾病中的诊断价值。方法：观察26例胃肠道癌患者（其中胃癌10例，结肠癌7例，直肠癌9例）和胃肠良性疾病（胃炎、肠炎、息肉）以及26例健康体检者外周血CEA、CA19-9、CA72—4、CA242的量，并进行分析、比较组间差异。结果：与健康对照组相比，胃肠道恶性肿瘤，胃肠炎症、息肉中CEA、CA19-9、CA72-4、CA242指标水平及阳性率均具有统计学差异（p〈0．05）CEA、CA19—9、CA72-4、CA242联合检测在诊断胃癌、结肠癌和直肠癌中的敏感性最高，分别达到了100％、86％和100％。结论：联合检测CEA、CA19-9、cA72—4、CA2424项指标具有互补作用，能提高胃肠道疾病的检出率。
Objective： To investigate the clinical significance of combined detection of four tumor markers （CEA, CA19-9, CA242, CA72-4） for diagnosis of gastrointestinal disease. Methods： Detections of CEA, CA19-9, CA242, and CA72-4 were con- ducted in 26 cases of gastrointestinal cancers （10 cases of gastric cancer, 7 cases of colon cancer, 9 cases of colorectal cancer）, 26 cases of benign disease patients （gastritis, enteritis, polyp） , and 26 cases of normal healthy individuals. The contents and positive rates of four tumor markers among them were compared. Results： Compared with healthy control group, the levels and positive rates of CEA, CA19-9, CA72-4 and CA242 in patients with gastrointestinal cancers and gastrointestinal inflammation and polyps （P〈0.05）. Conclusion： Combined detection of four tumor markers may help to improve the diagnosis of gastrointestinal disease.
出处
《医学检验与临床》
2016年第7期1-3,共3页
Medical Laboratory Science and Clinics
关键词
胃肠道肿瘤
诊断
肿瘤标志物
联合检测
Gastrointestinal cancer
Diagnosis
Tumor marker
Combined detection
