血清生化指标联合检测在重症手足口病的早期诊断价值

Early diagnosis value of serum biochemical indicators combined detection, in severe hand-foot and mouth disease

目的：探讨血清生化指标在重症手足口病的早期诊断价值。方法：将210例手足口病患者（HFMD）分为两组，其中轻症患者163例，重症患者47例，另外选60例健康体检者作为正常对照。三组都进行血清生化指标检测，包括肌酸激酶（CK）、肌酸激酶同工酶（CK—MB）、肌钙蛋白（cTnI）、血清前白蛋白（PA）、血糖（GLU），比较三组之间的差异。结果：HFMD患者血清CK、CK—MB、cTnI、GLU指标均显著高于正常对照组，而PA显著低于对照组，差异有统计学意义（P〈0．05）。重症患者CK、CK—MB、cTnI、GLU指标显著高于轻症患者，而pA显著低于轻症患者，差异有统计学意义（P〈0．05）。结论：联合检测血清生化指标cK、cK—MB、cTnI、GLU、PA可以对重症手足口病做出早期诊断，有效提高治疗效果。

Objective： The present study aims to analyze the biochemical indicators in severe hand foot and mouth disease （HFMD） . Methods： A total of 210 infants with HFMD were divided into mild group, （163 cases） ,severe group （47 cases） ,and an- other 60 healthy children served as control group. The biochemical indicators were detected and compared, including CK, CK-MB, cTnI, PA, GLU. Result： CK, CK-MB ,GLU and cTnI were higher in mild and severe groups than in control group. These bio-chemical indicators were higher ill severe group than in mild group. Conclusion： The early detection of CK, CK-MB, GLU and cTnI in the blood of infants with HFMD can diagnose HFMD early so as to improve the prognosis.