新生儿阳性标本细菌分布及耐药性分析

Newborn positive specimen bacterial distribution and drug resistance analysis

目的：了解新生儿培养标本细菌分布及耐药性，为临床合理选择抗菌药物提供依据。方法：采用回顾性的方法统计分析新儿科124份阳性标本细菌分布及耐药性。结果：124份阳性标本中前4位分别是肺炎克雷伯菌、金黄色葡萄球菌、表皮葡萄球菌和大肠埃希菌。肺炎克雷伯菌对氨苄青霉素耐药，对美罗培南、亚胺硫霉素、环丙沙星等敏感。大肠埃希菌对头孢唑啉和氨苄青霉素耐药，对哌拉西林、美罗培南和亚胺硫霉素等敏感。金黄色葡萄球菌和表皮葡萄球菌对青霉素和红霉素耐药，但对利奈唑胺敏感。结论：新生儿感染细菌有较高的耐药率，为提高患儿治愈率，应及时了解标本培养结果以便临床合理用药。

Objective： To investigate the distribution and drug resistance of newborn bacterial samples, and to provide the basis for clinical rational utilization of antibiotics.Methods： The distribution and drug resistance of 124 culture pathogens were analyzed by a retrospective statistical methodology.Results： The bacteria with higher isolated rate were K.pneumoniae,S.aureus,S.epidennidis and E.coli from 124 positive samples.K.pneumoniae was resistant to ampicillin, but was susceptible to meropenem, imipenem and ciprofloxacin.E.coli was resistant to ampicillin and cephazolin, but was susceptible to piperacillin, meropenem and imipenem. S.aureus and S.epidermidis were resistant to penicillin and erythromycin, but were susceptible to linezolid.Conclusion： The cultured pathogens of newborn are highly drug resistant. It is necessary to understand the culture result in a timely manner so as to use antibiotics reasonably and improve the cure rate of the patients.