胎儿颈部透明带增厚与不良妊娠结局的关系

The correlation between nuchal translucency(NT) thickening of the neck of the fetus and the outcome of adverse pregnancy

目的探讨胎儿颈部透明带(nuchal translucency,NT)增厚与不良妊娠结局的关系。方法随访观察1621例门诊行NT检查的单胎孕妇中NT≥2.5 mm的孕妇产前检查情况及妊娠结局。结果 NT≥2.5 mm的胎儿54例,经过无创DNA检查或羊水穿刺检查显示,共有9名染色体异常;NT增厚、孕妇年龄增加,染色体异常的检出率增加(P<0.05)。NT增厚且无染色体异常的45例孕妇中查出胎儿先天性心脏病3例,胎儿全身水肿2例,脐膨出2例,骨骼异常2例,自然流产2例;正常健康出生34例。结论孕早期超声检查胎儿NT,有利于早期筛查胎儿染色体异常尤其21-三体综合征,对于预测胎儿不良妊娠结局有重要的临床指导意义。

Objective To investigate the correlation between nuchal translucency（ NT） thickening and adverse pregnancy outcome. Method The outcomes of prenatal examination and pregnancy of 1621 singleton pregnant women with NT ≥2.5mm who underwent NT were examined. Findings 54 cases were found to have thickening greater than or equal to 2. 5mm.Non-invasive DNA examination or inspection of amniotic fluid puncture indicated a total of nine chromosomal abnormalities.As NT thickening and maternal age increased,chromosome abnormal detection rate increased. NT thickening and no chromosomal abnormalities of 45 cases of pregnant women found fetal congenital heart disease 3 cases,2 cases of fetal anasarca,2 cases of omphalocele,skeletal abnormalities in 2 cases,2 cases of spontaneous abortion; healthy birth 34 cases. Conclusion Prenatal ultrasound examination of fetal NT,which is conducive to the early screening of fetal chromosomal abnormalities,especially the 21-three body syndrome,has important clinical significance for the prediction of fetal adverse pregnancy outcome.